The emergence of new immunotherapies as the first line of treatment for cancer, necessitates the development of clinically useful biomarkers to select responders that
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In this Cell Press Webinar, Garry Nolan (Stanford University), Nadav Yayon (Wellcome Sanger Institute) and Atul Deshphande (Johns Hopkins Kimmel Cancer Center) discuss how advances in spatial omics technologies can elucidate human tissue architecture and its impacts on physiology and disease.
This Nature Research webcast will feature Aaron Mayer, PhD (Enable Medicine) presenting the use of a 51-plex panel that covers a range of functional and tumor microenvironment-related biomarkers, including lymphoid and myeloid cell markers, tissue biomarkers, antigen presenting cells, and immune checkpoint and activation markers.
Based on examples from different disease areas, including cancer, chronic inflammatory bowel disease, and renal transplantation, the discussion will cover current perspectives for on spatial pattern recognition as well as caveats and technical limitations to be considered when multiplexing technologies are applied in the area of clinical biomarker research.
Tertiary lymphoid structures (TLS) are ectopic cellular hubs that coordinate immunity within patient tumors. TLS also correlate with improved prognosis and superior response to immunotherapy. While secondary lymphoid organs (SLOs) are used for an initial definition of TLS, in depth spatial imaging is necessary to understand differences within TLS in various solid tumors. In this webinar, Dr. Bruno will discuss the varying TLS types in the tumor microenvironment (TME) and new discoveries on the definition of a TLS.
Breakthrough spatial biology applications such as spatial phenotyping span the discovery-to-clinical continuum. To minimize time and maximize value along the continuum, it is imperative to make discoveries happen faster and at scale. Identifying patients likely to achieve benefit remains an unmet clinical need. The tumor microenvironment (TME) is now recognized as a driving factor dictating response to immunotherapies.
This Nature webcast will present comprehensive, cell-by-cell, spatial phenotyping of a head and neck tumor to delineate tissue signatures associated with response to therapy.
In this webinar, Dr. med. Christian Schürch discuss how he is using spatial phenotyping technology to predict patient response to immunotherapy in various cancers. Learn about coordinated cellular neighborhoods and the important roles they play in antitumoral immunity. Discover how spatial distances between different cell types in the TME cells are associated with immunotherapy outcomes. And gain insights into which emerging spatial biology techniques enable implementation of simplified spatial scores to enable clinical decision making and improve prediction for cancer immunotherapy.
We are pleased to invite you to our second annual Spatial Day. Spatial Day is about bringing together academic, clinical, and industry leaders to highlight how spatial phenotyping is uniquely suited to addressing key questions across discovery, translational, and clinical research.
Spatial phenotyping is a transformational new tool delivering an unprecedented understanding of disease biology. Mark your calendar and get ready to learn about the latest breakthroughs and innovations from Akoya as we trailblaze the future of spatial phenotyping.
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