Featured Video

How has spatial imaging gone from ‘heroic experiment’ to a must-have tool for a wide range of applications in a variety of labs? Peter Miller, Akoya’s vice president of research and development, walks us through the advancement of single-cell spatial biology tools, how user needs have influenced the evolution, and what the future holds as the technology moves from academic research labs into the clinic.

Could standard mIF assays make spatial biology technology more accessible in the clinic? Dana-Farber scientist Kathleen Plaff talks about how her lab is developing a six-marker pan-cancer panel, ImmunoProfile, to help simplify the characterization of the tumor-immune microenvironment for researchers, as well as a national collaboration to facilitate the incorporation of spatial biology data into immunotherapy trials.

What’s it like for a CRO to provide spatial imaging services for a range of customer needs? BostonGene associate director Zhongmin Xiang shares examples of work done in his lab, as well as strategies the lab has developed, from custom panels and lab-developed tests to AI-based analysis tools, RNAseq deconvolution methods, and high-level profiling summaries.

Among the challenges in treating pancreatic cancer is the lack of reliable genomic biomarkers to help select the appropriate treatment. Could high-resolution, spatially resolved tissue analysis help identify targetable pathways that regulate the pancreatic cancer microenvironment, with implications for expanded or more efficient treatment options?

Spatially resolved transcriptomics of tissue sections enables advances in fundamental and applied biomedical research, and the Fan Lab at Yale University developed microfluidic chips and the DBiT-seq (Deterministic Barcoding in Tissue) protocol to spatially encode mRNAs in various types of tissue. In this video, Archibald Enninful details how the team combined their transcriptome workflow with the PhenoCycler® -Fusion in order to leverage its single-cell resolution and drill deeper into cell populations.

Peter Miller, Akoya’s vice president of research and development, guides the day’s speakers through a series of questions about their experiences working with RNA and spatial biology.