The PhenoCycler Solution

Spatial Discoveries at Scale

We’ve rebranded some of our products, learn more ›

CODEX is now PhenoCycler
Phenoptics is now Phenolmager

PhenoCycler – Rapid, Deep Spatial Phenotyping

Characterizing the complexities of the tissue microenvironment is critical in understanding the molecular and cellular mechanisms to unravel insights into disease development, differentiation, and response. The PhenoCycler™-Fusion allows spatial phenotyping of millions of cells at unprecedented scale and speed. Mapping millions of cells and their interactions in a single intact tissue section facilitates the discovery of rare cell types, cellular neighborhoods, and spatial functional states. Push the frontiers of spatial biology with your team using the PhenoCycler solutions (formerly CODEX®).

Benefits

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Fast

Sample-To-Data Within
24 Hours
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Unbiased

Whole-Slide Imaging at Single-Cell Resolution
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Ultrahigh-plex

Image 100+ Biomarkers
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Flexible

Compatible With Any Sample Type

Case Studies

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Rare Cells and Cellular Neighborhoods: Novel Discoveries from Spatial Phenotyping
Explore how whole-tissue, single-cell imaging enabled the study of a rare cell type and the impact of cellular neighborhoods on tumor progression
Pushing the Frontiers of CAR T-cell Therapy:
A Spatial Analysis of Solid Tumors
See how to use PhenoCycler, a single-cell spatial phenotyping solution, to characterize the microenvironment of various pediatric tumors and to understand the potential interactions that chimeric antigen receptor (CAR) T cells may elicit.
CAR T Cell Interaction Heat Map
Spatial Multiomics: Enriching Single-Cell Sequencing Data with Spatial Phenotyping
In this multi-part webinar series, our expert speakers review analytical frameworks and algorithms to integrate imaging-based single-cell spatial phenotyping data with complementary transcriptomic and genomic datasets.

Imaging Gallery

Technology

Watch this video to learn how the PhenoCycler instrument uses the reveal, image, remove workflow to spatially phenotype cells while retaining tissue context and maintaining sample integrity. Learn how this simple but practical instrument gives you unmatched flexibility to phenotype every single cell across the whole slide giving access to unbiased spatial phenotyping.

Workflow

Related Publications

Coordinated cellular neighborhoods orchestrate antitumoral immunity at the colorectal cancer invasive front
2020 Sep 03
This study provides a framework for interrogating how complex biological processes, such as antitumoral immunity, occur through concerted actions of cells and spatial domains.
An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy, and immunotherapy in bladder cancer
2021 Aug 12
This study combines single-cell sequencing data and CODEX to identify epithelial subpopulations with therapeutic response prediction ability in bladder cancer.
Technological advances in cancer immunity: from immunogenomics to single-cell analysis and artificial intelligence
2021 Aug 20
Summary of conventional and state-of-the-art technologies in the field of immunogenomics, single-cell and artificial intelligence, and present prospects for future research.