The Inside Scope

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The October 2021 Image Contest: Meet the Winners

After an amazing turnout for our first social media image contest, we decided to hold another. We asked our followers on LinkedIn and Twitter to submit their most eye-catching tissue images, and they did not disappoint. Our judges had a tough time choosing the top three winning images. Check out their picks and the scientists behind them...

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Webinar Rewind: Pushing the Frontiers of CAR T-Cell Therapy

Pediatric cancer is an urgent and important problem that requires highly precise diagnostics and therapeutic approaches, however many of the necessary tools have yet to be developed. Around 60% of pediatric cancers are solid tumors, and the prognosis of these cancers is poor with mortality as high as 40%. Advanced solid tumors are highly complex and extremely successful at evading the immune response. Dr. David Steffin, a pediatric oncologist and assistant professor...

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Spatial Multiomics: The Need for Multidimensional Analysis with Single-Cell, Spatial Context

Researchers studying the dynamics of disease and development are increasingly relying on approaches that enable spatial analysis of RNA and protein markers within tissue. Tools like spatial proteomics and spatial transcriptomics are instrumental in answering complex biological questions. However, biological processes are driven by changes that occur simultaneously across multiple modalities. Transcriptomics and proteomics provide unique information...

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Spatial Analysis with Seurat: Unlocking Single-Cell Insights from CODEX Data

Seurat is an R package developed by Rahul Satija’s lab at the New York Genome Center. A widely used, open-source tool for single-cell analysis, Seurat was designed to explore single-cell RNA sequencing data. Seurat can also be applied to multiplex imaging-based spatial phenotyping data generated with CODEX®. Bioinformatics Field Application Scientist, Grady Carlson, PhD, shared the steps for using Seurat to analyze CODEX datasets...

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Meet the Winners of the Akoya Image Contest

We recently held a social media image contest inviting our followers to show off a fun activity or theme using tissue images. After receiving some incredibly creative submissions, it’s time to announce the winners! Here are the top three participants with the most likes and/or reactions on their social media posts...

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The Intricate Network of Immune Cells Revealed by Multiplex Tissue Microscopy

When our immune systems identify invaders – such as parasites, bacteria or viruses – it can spark inflammation, which brings fluid and immune cells to the area of infection. While this can be very effective in battling infection, it also has collateral damage on nearby healthy tissues. In our daily lives, just by eating or breathing, we are constantly exposing our immune systems to microbes and particulate matter that can elicit low level inflammatory responses...

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Show Off Your Creativity by Participating in the Akoya Image Contest: Four Examples from Our Team

Our social media image contest is in full swing! We’re inviting all our followers to get creative and show off your interests with tissue images. Here’s how you can enter. Either produce a tissue image using one of Akoya’s platforms or find one on our website. Then, put your creative skills to use and edit the image to show off a fun activity or theme. Share those images on LinkedIn, Twitter, or both. Be sure to follow and tag us and use the hashtag #AkoyaImageContest...

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Multi-Institutional Efforts to Standardize Multiplex Immunofluorescence for Spatial Biomarker Analysis

In the era of immunotherapy, it’s essential to match the right patient to the right treatment. Effective biomarkers are needed to enable patient stratification and ensure that more patients benefit from precision medicine. While many novel techniques have been developed to aid scientists in their hunt for better immunotherapy biomarkers, spatial phenotyping has emerged as a frontrunner in this quest. A comprehensive meta-analysis published in JAMA Oncology...

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Multispectral Multiplex Immunofluorescence: Laying the Groundwork for Clinical Testing in Immuno-Oncology

There is a pressing need for tests that can accurately predict response to immunotherapies, writes Cliff Hoyt, our VP of Translational & Scientific Affairs, in a review article for Frontiers in Molecular Biosciences. Established methods are limited in the amount of information they can pull out of formalin- fixed, paraffin-embedded (FFPE) tissue sections. Conventional immunohistochemistry (IHC), for example, is constrained to one or two protein markers, which...

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