We’ve rebranded some of our products, learn more ›
CODEX is now PhenoCycler
Phenoptics is now Phenolmager
Spatial Phenotyping That Meets Your Throughput Needs
Leveraging patented multispectral imaging (MSI) technology, the PhenoImager® solution (formerly Phenoptics™) provides you with an accurate quantitative assessment of multiple immune phenotypes while capturing their tissue context and spatial distribution within the tumor microenvironment (TME).
This powerful but easy-to-use digital pathology slide scanning platform enables researchers to develop more relevant and highly predictive biomarkers, called spatial signatures (see PhenoCode™ Signature Panels), to characterize tumor and immune cells by function and state in the context of an intact tissue sample.
The PhenoImager Fusion and the PhenoImager HT systems are both capable of rapid whole slide scanning with multispectral imaging.
Instruments
PhenoImager Fusion – Spatial Signatures Within Reach
PhenoImager Fusion functions as a standalone ultrafast slide scanner ideal for standard throughput and high-plex spatial phenotyping applications. PhenoImager Fusion also integrates with the PhenoCycler™ instrument (formerly CODEX®) for spatial discovery at scale.
Enhanced Workflow Efficiency:- Brightfield and fluorescence imaging
- 6-plex whole slide scans in under 20mins (see newly launched PhenoCode Signature Panels)
- 4-slide capacity and easy integration with the PhenoCycler instrument to enable ultrahigh-plex (100+ biomarkers/slide) imaging
PhenoImager HT – Spatial Signatures at Scale
The PhenoImager HT is the premier and most highly cited digital pathology imager for spatial phenotyping. Featuring whole-slide multispectral scanning, this system can be easily integrated into high-throughput workflows that need to accommodate for scalability.
Power of multispectral imaging in a high throughput workflow:- Brightfield and fluorescence imaging
- 6-plex whole slide scans in under 20mins (see newly launched PhenoCode Signature Panels)
- 80 slide capacity with continuous loading technology
PhenoImager Selection Guide
| PhenoImager Fusion | PhenoImager HT | |
|---|---|---|
| Tissue Formats | Tissue microarrays and tissue sections | Tissue microarrays and tissue sections |
| Slide Scanner Capacity | 4-slide capacity | 80-slide capacity (with continuous loading technology) |
| Detection Method | Fluorescence, Brightfield | Fluorescence, Brightfield |
| Light Source | LED | LED |
| Multiplexing Capability | Separates up to 7 colors, even if overlapping | Separates up to 9 colors, even if overlapping |
| Resolution | 40x = 0.25 μm/pixel 20x = 0.5 μm/pixel 10x = 1.0 μm/pixel | 40x = 0.25 μm/pixel 20x = 0.5 μm/pixel 10x = 1.0 μm/pixel |
| Automation | Touchless, with walk-away image acquisition | Touchless, with walk-away image acquisition |
Related Publications
A Standardized Analysis of Tertiary Lymphoid Structures in Human Melanoma: Disease Progression- and Tumor Site-Associated Changes With Germinal Center Alteration
This study from the Medical University of Vienna used 6-plex multiplex immunostaining of whole tissue sections to analyze TLS phenotypes, density and spatial distribution in human melanoma
Immune and tumor cell-derived CXCL10 in melanoma
This study from the University of Chicago focuses on the identification of cell populations producing CXCL10 in the tumor microenvironment which plays an important role in clinical response to immunotherapy in metastatic melanoma.
Infiltrating T cell and liver transplant rejection
Scientists from Capital Medical University in Beijing explore the role of infiltrating T cells in the rejection of allogeneic liver transplantation.
Related Resources
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Literature
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Case Studies
Literature
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