The PhenoImager Instruments

Uncover spatial phenotypic signatures

We’ve rebranded some of our products, learn more ›

CODEX is now PhenoCycler
Phenoptics is now Phenolmager

Spatial Phenotyping That Meets Your Throughput Needs

image-fusion

Leveraging proprietary multispectral imaging (MSI) technology (patent pending), the PhenoImager™ solution (formerly Phenoptics™) provides you with an accurate quantitative assessment of multiple immune phenotypes while capturing their tissue context and spatial distribution within the tumor microenvironment (TME).

This powerful but easy-to-use digital pathology platform enables researchers to develop more relevant and highly predictive biomarkers, called spatial phenotypic signatures, to characterize tumor and immune cells by function and state in the context of an intact tissue sample.

The PhenoImager Fusion and the PhenoImager HT systems are both capable of rapid whole slide, multispectral imaging. Find the system that best suits your needs.

Instruments

PhenoImager Fusion – Spatial Signatures Within Reach

image-fusion

The PhenoImager Fusion system enables whole-slide, multispectral imaging (MSI) at single-cell resolution at unprecedented speed. Ideal for standard throughput, high-plex applications, PhenoImager Fusion can function as a standalone ultrafast imager for spatial phenotyping applications or can be integrated with the PhenoCycler™ instrument (formerly CODEX®) for spatial discovery at scale.

Enhanced Workflow Efficiency:
  • Whole-slide scans at 40x magnification for up to
    6 biomarkers per slide in under 20 minutes
  • 4-slide capacity and easy integration with the PhenoCycler instrument to enable ultrahigh-plex
    (100+ biomarkers/slide) imaging
  • Touchless, walk-away digital pathology image acquisition

PhenoImager HT – Spatial Signatures at Scale

PhenoImager-HT-Spatial-Signatures

The PhenoImager HT is the premier and most highly cited digital pathology imager for spatial phenotyping. Featuring whole-slide multispectral scanning, this system can be easily integrated into high-throughput workflows that need to accommodate for scalability.

Power of multispectral imaging in a high throughput workflow:
  • Whole slide scans at 40x magnification of 7 colors in 20 mins
  • 80 slide capacity with continuous loading technology
  • Touchless, with walk-away digital pathology image acquisition

PhenoImager Selection Guide

PhenoImager Fusion PhenoImager HT
Tissue Formats Tissue microarrays and tissue sections Tissue microarrays and tissue sections
Slide Capacity 4-slide capacity 80-slide capacity (with continuous loading technology)
Detection Method Fluorescence, Brightfield Fluorescence, Brightfield
Light Source LED LED
Multiplexing Capability Separates up to 7 colors, even if overlapping Separates up to 9 colors, even if overlapping
Objectives 40x = 0.25 μm/pixel
20x = 0.5 μm/pixel
10x = 1.0 μm/pixel
40x = 0.25 μm/pixel
20x = 0.5 μm/pixel
10x = 1.0 μm/pixel
Automation Touchless, with walk-away image acquisition Touchless, with walk-away image acquisition

Related Publications

Effect of PKCλ/ι inhibition on tumorigenesis
Researchers from Weill Cornell Medicine demonstrate how PKC λ/ι loss activates a STING-mediated IFN signaling that triggers a CD8+ anti-tumor response.
Immune and tumor cell-derived CXCL10 in melanoma
This study from the University of Chicago focuses on the identification of cell populations producing CXCL10 in the tumor microenvironment which plays an important role in clinical response to immunotherapy in metastatic melanoma.
Infiltrating T cell and liver transplant rejection
Scientists from Capital Medical University in Beijing explore the role of infiltrating T cells in the rejection of allogeneic liver transplantation.

Related Resources

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