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Category: Publication Reviews

New spatial maps of the intestines, breast, and kidney reveal valuable insights

Bringing order to our inner cosmos: New spatial maps of the intestines, breast, and kidney reveal valuable insights

Learn about three new studies that shed further light on the hidden order within our tissues — using multiplexed imaging, spatial biology, and other technologies to reveal valuable insights into our inner world of cellular communities.
7-color multiplex immunofluorescence images of colorectal cancer from Crohn's like reaction and diffuse inflammatory infiltration patient groups and accompanying voronoi plots.

Spatial Analysis of Cellular Neighborhoods: Uncovering Complex Interactions in Tissue Biology

The tumor microenvironment is undeniably complex. Specialized immune cells interact directly and indirectly with tumor cells in a constantly evolving relationship that influences the biology of the tumor. Spatial context is essential to uncovering the mysteries of cell behavior and interactions. Just as individuals may behave differently in cities, suburbs,…
mitre-pd1pdl1-proximity

Multi-Institutional Efforts to Standardize Multiplex Immunofluorescence for Spatial Biomarker Analysis

In the era of immunotherapy, it’s essential to match the right patient to the right treatment. Effective biomarkers are needed to enable patient stratification and ensure that more patients benefit from precision medicine. While many novel techniques have been developed to aid scientists in their hunt for better immunotherapy biomarkers, spatial…
From astronomy to pathology with AstroPath

From Stars to Cells: Johns Hopkins Researchers Discover Predictive Spatial Phenotypic Signatures with AstroPath

One of the biggest questions in immuno-oncology is figuring out how patients will respond to immunotherapy. Approaches like single-plex immunohistochemical stains don’t capture enough information to accurately predict response. To help solve this challenge, researchers at Johns Hopkins University (JHU) developed AstroPath, a novel platform which combines…
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