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Spatiotemporal Determinants of T Cell Therapy in Cancer

Webinar | Tuesday, May 28, 2024

Advancements in single-cell multiplexed imaging coupled with sophisticated computational algorithms have greatly augmented our views into complex tissue microenvironments. In this seminar, Dr. Hickey will present the approaches he and his team have developed to deconstruct intricate tissue datasets and connect them across scales from molecular to multicell modules. Particularly, he will share a story how he and his team analyzed melanomas treated with effective and ineffective T cell therapies. 
Learning Objectives:

  • Explore the utilization of spatial technologies in analyzing tissue morphology before and after treatment. 
  • Understand the process of developing innovative computational algorithms and their application in assessing diverse datasets. 
  • Gain insights into advanced techniques for accurately identifying patients with potential for sustained response to T cell therapies. 




John Hickey

John Hickey, PhD

Assistant Professor of Biomedical Engineering, Duke University

John Hickey's Lab sits at the interface of engineering and immunology, using and developing systems immunology tools to investigate tissue structure in situ. They also use multiplexed imaging and computational techniques to characterize spatial cellular responses related to the effectiveness of anti-cancer cell or biomaterial therapies. John has received a number of awards for his work, including the NSF Graduate Research Fellowship, ARCS Scholar, Siebel Scholar, NCI Postdoctoral Fellowship, and American Cancer Society Postdoctoral Fellowship.