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Spatial Signature Panel Optimization and Reproducibility to Enable Tumor Immune Profiling

Original Air Date: June 13, 2022

Dr. Cara Haymaker and Dr. Edwin Parra discuss their research work within the Translational Molecular Pathology Immunoprofiling Laboratory (TMP-IL) at MD Anderson Cancer Center focused on the development and reproducibility of an automated nine-colour mIF panel to visualize and characterize the tumor microenvironment (TME). In this webinar, they will present their finding which demonstrate the power of multiplex imaging in exploring cellular phenotype proliferation in the TME and their geographic distribution, and spatial proximity of cell phenotypes related to malignant cells. This research has implications for the potential capability of the data obtained through this methodology for immune profiling FFPE tumor tissues in translational studies.

 

Key learning objectives:

  • Understand how multispectral imaging can be used to profile many different cell types in the tumor microenvironment.
  • Learn about the methods for the optimization and reproducibility of a 9-color multiplex immunofluorescence panel.

Video

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Speaker

Cara Haymaker, PhD

Assistant Professor, Translational Molecular Pathology
The University of Texas MD Anderson Cancer Center

Dr. Haymaker is an assistant professor at the department of translational molecular pathology and director of the TMP-IL platform at The University of Texas MD Anderson Cancer Center.Her research has focused on tumor-infiltrating lymphocytes and their immunologic characteristics in solid tumors. She has authored 78 peer-reviewed original research articles

Dr. Edwin Roger Parra Cuentas

Director, Multiplex Immunofluorescence and Image Analysis Laboratory
The University of Texas – MD Anderson Cancer Center

Dr. Parra is pathologist with a strong background in surgical pathology and an assistant professor in the Department of Translational Molecular Pathology at The University of Texas MD Anderson Cancer Center. As the Director of the Multiplex Immunofluorescence and Image Analysis Laboratory at MD Anderson Cancer Center, his group applies various staining techniques and imaging platforms to characterize the immune response to immunotherapy in longitudinal cancer studies to discover and develop new biomarkers for future treatment approaches. With over 100 peer-reviewed research articles, Dr. Parra is one of the leaders in the field of immune profiling using the various image analysis–based methodologies.