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Investigating Tertiary Lymphoid Structures in Solid Tumors

Original Air Date: July 27, 2022

Tertiary lymphoid structures (TLS) are lymph node-like organisations of immune cells within inflamed tissues that can drive immune cell activation. Solid tumours exhibit TLS development, which is associated with improved survival of untreated patients. Similarly, in patients treated with immune checkpoint inhibitors, TLS development is often associated with improved therapeutic response. This has prompted the hypothesis that TLS are sites where antitumor immunity is generated. For this webinar, the speaker will introduce what is already known about TLS, what the main open questions are, and what analysis approaches can be used to understand the biology of tumor-associated TLS.

In this webinar Dr. Silina will introduce what is already known about tertiary lymphoid structures (TLS), what the main open questions are, and what analysis approaches can be used to understand the biology of tumor-associated TLS.

In this Webinar You Will:

  • Learn about the development and function of tertiary lymphoid structures (TLS) in the cancer microenvironment
  • Discover the prognostic and predictive relevance of TLS in cancer
  • Find out about methods for in-depth characterization of TLS in human tissues

Video

Speaker

Karina Silina, Ph.D.

Swiss Federal Institute of Technology (ETH) Zurich, Switzerland