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Australia Spatial Day 2023 (Brisbane)

Original Air Date: Tuesday, July 18, 2023

Spatial day aims to bring together academic and clinical researchers to share the latest advances in spatial biology, and how these cutting-edge applications have been used to address key questions across discovery and translational research a range of disease area.

Highlights: Introduction to the fastest spatial proteomics platform, the PhenoCycler-Fusion. Spatial biology research breakthroughs by Queensland researchers in immuno-oncology and cancer. Explore how spatial technologies can be used to uncover biology for various disease area.

Uncovering New Insights in Tumor Biology and Beyond




Clemens Duerrschmid

Clemens Duerrschmid, PhD

Sr. Technical Application Scientist, Akoya Biosciences

Spatial Precision Oncology: Stratifying Immunotherapy Response in Hepatocellular Carcinoma




Ankur Sharma

Ankur Sharma, Ph.D.

Laboratory Head, Harry Perkins Institute of Medical Research and Curtin University

Multi-omic Spatial Delineation of Immunotherapy Response

Dr. Arutha Kulasinghe discusses how single-cell multiomic spatial phenotyping is an invaluable tool to characterize the tumor microenvironment using unbiased whole-slide imaging of metastatic/recurrent HNSCC tumors among patients treated with pembrolizumab/nivolumab. He also explains how using these techniques, his team were able to identify stromal, immune, and metabolic tissue signatures associated with resistance to immunotherapy and poor overall survival.




Arutha Kulasinghe

Arutha Kulasinghe, PhD

NHMRC Research Fellow, Clinical-oMx Lab Head, The University of Queensland, Australia

The Activation Status and Spatial Distribution of Hofbauer Cells in Malawian Placentas with Active, Past, or No Malaria: Insights from an Opal Multiplex Study




Ricardo Ataide

Ricardo Ataíde, PhD

Senior Research Fellow, Walter and Eliza Hall Institute, Peter Doherty Institute

Spatial Imaging and Phenotypic Analysis of Immune Cells and Malaria Parasites in Plasmodium Infected Human Spleens




Dean Andrew QIMR Berghofer

Dean Andrew

Research Assistant, QIMR Berghofer Medical Research Institute

Clinical Implementation of Spatial Proteomic Data for Cancer Treatment Personalization




Jazmina Gonzalez Cruz

Jazmina Gonzalez Cruz, PhD

Senior Research Fellow, Frazer Institute Faculty of Medicine

Tertiary Lymphoid Structures (TLS) in Solid Tumors

Dr. Jessica Da Gama Duarte from Olivia Newton-John Cancer Research Institute presents a protocol for the in situ interrogation and characterization of TLSs in human and murine tissue sections using multiplex immunohistochemistry. This protocol enables simultaneous detection of up to 7 markers (6 antigens and a DAPI counterstain). She also describes a grading system to identify immature and mature TLSs.




Dr Jessica Da Gama

Jessica Da Gama Duarte, PhD

Postdoctoral Research fellow, Olivia Newton-John Cancer Research Institute, Australia