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Tumor cell PD-L1 expression is a strong predictor of unfavorable prognosis in immune checkpoint therapy-naive clear cell renal cell cancer

Authors: Möller, Katharina; Fraune, Christoph; Blessin, Niclas C.; Lennartz, Maximilian; Kluth, Martina; Hube-Magg, Claudia; Lindhorst, Linnea; Dahlem, Roland; Fisch, Margit; Eichenauer, Till; Riechardt, Silke; Simon, Ronald; Sauter, Guido; Büscheck, Franziska; Höppner, Wolfgang; Matthies, Cord; Doh, Ousman; Krech, Till; Marx, Andreas H.; Zecha, Henrik; Rink, Michael; Steurer, Stefan; Clauditz, Till S.

Online: https://doi.org/10.1007/s11255-021-02841-7

Issue: Int Urol Nephrol . 2021 Apr 1. doi: 10.1007/s11255-021-02841-7.

Abstract

PD-L1 expression predicts response to immune checkpoint inhibitors in renal cell carcinomas (RCC), but has also been suggested to be linked to poor patient outcome.