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Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer’s disease

Authors: Cherry, Jonathan D.; Esnault, Camille D.; Baucom, Zachary H.; Tripodis, Yorghos; Huber, Bertrand R.; Alvarez, Victor E.; Stein, Thor D.; Dickson, Dennis W.; McKee, Ann C.

Online: https://doi.org/10.1186/s40478-021-01189-4

Issue: Acta Neuropathol Commun. 2021 May 12;9(1):86.


Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease, characterized by hyperphosphorylated tau, found in individuals with a history of exposure to repetitive head impacts. While the neuropathologic hallmark of CTE is found in the cortex, hippocampal tau has proven to be an important neuropathologic feature to examine the extent of disease severity. However, the hippocampus is also heavily affected in many other tauopathies, such as