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T-regulatory cells predict clinical outcome in soft tissue sarcoma patients: a clinico-pathological study

Authors: Smolle, Maria A.; Herbsthofer, Laurin; Granegger, Barbara; Goda, Mark; Brcic, Iva; Bergovec, Marko; Scheipl, Susanne; Prietl, Barbara; Pichler, Martin; Gerger, Armin; Rossmann, Christopher; Riedl, Jakob; Tomberger, Martina; López-García, Pablo; El-Heliebi, Amin; Leithner, Andreas; Liegl-Atzwanger, Bernadette; Szkandera, Joanna

Online: https://www.nature.com/articles/s41416-021-01456-0

Issue: Br J Cancer. 2021 Jun 14.


Soft tissue sarcomas (STS) are generally considered non-immunogenic, although specific subtypes respond to immunotherapy. Antitumour response within the tumour microenvironment relies on a balance between inhibitory and activating signals for tumour-infiltrating lymphocytes (TILs). This study analysed TILs and immune checkpoint molecules in STS, and assessed their prognostic impact regarding local recurrence (LR), distant metastasis (DM), and overall survival (OS).