We’ve rebranded some of our products, learn more ›

CODEX® is now PhenoCycler,
Phenoptics™ is now Phenolmager.

Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence

Authors: Kohnke, Sara; Buller, Sophie; Nuzzaci, Danae; Ridley, Katherine; Lam, Brian; Pivonkova, Helena; Bentsen, Marie A.; Alonge, Kimberly M.; Zhao, Chao; Tadross, John; Holmqvist, Staffan; Shimizo, Takahiro; Hathaway, Hannah; Li, Huiliang; Macklin, Wendy; Schwartz, Michael W.; Richardson, William D.; Yeo, Giles S. H.; Franklin, Robin J. M.; Karadottir, Ragnhildur T.; Rowitch, David H.; Blouet, Clemence

Online: https://www.sciencedirect.com/science/article/pii/S2211124721007609

Issue: Cell Rep. 2021 Jul 13;36(2):109362.


“The mediobasal hypothalamus (MBH; arcuate nucleus of the hypothalamus [ARH] and median eminence [ME]) is a key nutrient sensing site for the production of the complex homeostatic feedback responses required for the maintenance of energy balance. Here, we show that refeeding after an overnight fast rapidly triggers proliferation and differentiation of oligodendrocyte progenitors, leading to the production of new oligodendrocytes in the ME specifically. During this nutritional paradigm, ME perineuronal nets (PNNs), emerging regulators of ARH metabolic functions, are rapidly remodeled, and this process requires myelin regulatory factor (Myrf) in oligodendrocyte progenitors. In genetically obese ob/ob mice, nutritional regulations of ME oligodendrocyte differentiation and PNN remodeling are blunted, and enzymatic digestion of local PNN increases food intake and weight gain. We conclude that MBH PNNs are required for the maintenance of energy balance in lean mice and are remodeled in the adult ME by the nutritional control of oligodendrocyte differentiation.

Keywords: energy balance; glucose homeostasis; hypothalamus; median eminence; nutrition; obesity; oligodendrocyte; perineuronal nets; plasticity.”