Nature declared single-cell multimodal omics to be the 2019 Method of the Year. This follows the entrenchment of single-cell transcriptome analyses as household tools in biological and clinical research. Single cell transcriptome analyses offer unprecedented access to study cellular heterogeneity and tissue organization, but they remain limited. They provide information solely about the transcriptomic state of a cell. They also come at the expense of spatial information, which prevents accurate reconstruction and analysis of cellular microenvironments.