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Immune checkpoint inhibitors are revolutionizing cancer therapy and have helped many patients over the past few years. Yet, researchers and clinicians still lack reliable and robust biomarkers to predict patients who are more likely to benefit from these therapies. A team of investigators at the Mayo Clinic is trying to close this gap by developing a catalog of the human immune system in cancer patients, appropriately called “The Cancer Immunome Project.”

The project seeks to describe the dynamics of immune interactions at both the systemic level — through cytometric analysis of peripheral blood -- and the local level, through single-cell, multiplex immunofluorescence-based imaging of the tumor microenvironment. By analyzing the spatial architecture of FFPE tumor sections across the entire tumor microenvironment, the team is generating a comprehensive map of the cancer immunome.

In this webcast, Dr. JC Villasboas will share how his team is using the CODEX^® System to deepen our knowledge about the composition, architecture and interactions of the tumor microenvironment.

Explore:

• How spatial phenotyping can generate high resolution maps of millions of cells in an FFPE tumor section
• How to design multiplex panels for the CODEX^® System
• How to use spatial analysis tools to profile the tumor immune microenvironment

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