Video Tag: PhenoImager (Phenoptics)

Lisa Butterfield, Ph.D., President of the Society of Immunotherapy of Cancer and Bernard Fox, Ph.D. Harder Family Endowed Chair in Cancer Research discuss the impact of multiplex tissue analysis on immuno-oncology research and translational studies.

Mini-semina with Cliff Hoyt, VP of Translational and Clinical Programs at Akoya Biosciences, showing how the MOTIF™ technology can unmix an entire digital slide and how this reveals the biology. This particular sample is a melanoma FFPE slide stained with the Opal Polaris 7 Color Kit.

Mini-seminar where Cliff Hoyt, VP of Translational and Clinical Programs at Akoya Biosciences, shows the importance of unmixing and isolating autofluorescence from your multiplexed samples. This lymphoma biopsy sample was stained using the Opal Polaris 7 Color Reagent Kit.

This brief video explains how using biomarkers on tissue samples not only provides new insights into the biology of cancer but ultimately enables a new level of patient stratification.  This allows the most effective treatment to be used for any given cancer leading to significantly improved outcomes for patients.

True multiplex tissue analysis enables multiple biomarkers to be identified and spatial relationships between different cell types to be analyzed. The Vectra Polaris System provides a high throughput solution from Opal staining to whole slide imaging and multi-parameter image analysis for a deeper understanding of biology.

Bernard Fox, Ph.D., Harder Family Endowed Chair in Cancer Research at the Earle A. Chiles Research Institute, discusses key finding from the SITC Immunoscore Validation Project.  The ability to clearly discriminate between tumors with or without immune cell infiltrates is critical to properly stratifying patients for interventional treatments.

In this short video, Akoya Biosciences® Opal Applications Leader, Virginie Goubert, walks us through the streamlined Opal Multiplex Fluorescent IHC assay development and optimization process. Learn to speed up development time by following this simplified experimental design, leading to balanced signals, full dynamic expression of each marker, and faster quantitative results.

This brief overview shows the power of multispectral imaging to unlock the full potential of spatial biology. This includes a discussion of the confounding effects of cross-talk between spectra and how this limitation has been successfully addressed with spectral-unmixing.