Immunology

The Importance of Antibody Validation

One of the most critical steps in multiplexed antibody panel design is selecting the right antibodies for your study. Choose the wrong antibody and you may lose weeks if not months, worth of work. An rigorous antibody validation strategy keeps your program on track by: Proving antibody specificity (the antibody’s ability to differentiate between various antigens), Proving affinity (antibody-epitope binding intensity)…

The Intricate Network of Immune Cells Revealed by Multiplex Tissue Microscopy

A ZEISS Microscopy User Story When our immune systems identify invaders – such as parasites, bacteria or viruses – it can spark inflammation, which brings fluid and immune cells to the area of infection. While this can be very effective in battling infection, it also has collateral damage on nearby healthy tissues. In our daily …

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Tissue images showing progression of gut GvHD

Webinar Rewind: A Single-Cell GPS to Discover Novel Spatial Biomarkers in FFPE Tissues

As part of a study on graft-versus-host disease  in the gut mucosa, Kohta Miyawaki, PhD, Physician-Scientist at Kyushu University partnered with Aaron Mayer, Chief Scientific Officer at Enable Medicine to perform multiplex imaging of gut GvHD samples using the CODEX platform. They discussed the results from their study in a recent webinar. In this blog …

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Customer Spotlight: A Deeper Understanding of Cardiac Transplant Rejection

Heart transplant rejection is a common occurrence, affecting 24% of patients within a year of the procedure. Acute cellular rejection is behind most cases, occurring when antigens on the allograft trigger a response from cytotoxic T cells. Less clear is the mechanism behind antibody-mediated rejection, which involves donor-specific antibodies binding to target antigens and activating …

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