Immuno-Oncology

SITC 2021: Spatial Biology Poised to Address Challenges in Immuno-Oncology

Studies in recent years have established that the spatial arrangements of cells hold information crucial to understanding immunotherapy response. In a study published in the Journal for ImmunoTherapy of Cancer (JITC), Lu et al. found that multiplex imaging-based approaches like multiplex immunohistochemistry (mIHC) and immunofluorescence (mIF) had much higher predictive power compared to single-plex PD-L1 IHC or single-cell sequencing. Those findings were reflected at this year’s Society for Immunotherapy of Cancer (SITC) Annual Meeting…

Webinar Rewind: Pushing the Frontiers of CAR T-Cell Therapy

Pediatric cancer is an urgent and important problem that requires highly precise diagnostics and therapeutic approaches, however many of the necessary tools have yet to be developed. Around 60% of pediatric cancers are solid tumors, and the prognosis of these cancers is poor with mortality as high as 40%. Advanced solid tumors are highly complex and extremely successful at evading the immune response. Dr. David Steffin, a pediatric oncologist and assistant professor…

Multi-Institutional Efforts to Standardize Multiplex Immunofluorescence for Spatial Biomarker Analysis

In the era of immunotherapy, it's essential to match the right patient to the right treatment. Effective biomarkers are needed to enable patient stratification and ensure that more patients benefit from precision medicine. While many novel techniques have been developed to aid scientists in their hunt for better immunotherapy biomarkers, spatial phenotyping has emerged as …

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