Cancer Archives

Collaborating with Agilent to Catalyze Precision Medicine

Collection: Akoya Perspectives
Tags: Cancer, Immuno-Oncology, Immunotherapy, Spatial Analysis

Learn about our recent partnership with Agilent to drive multiplex tissue assay development for biopharma applications and find out why spatial signatures represent a paradigm shift in immunotherapy predicitive biomarkers.

AACR 2022: Dialing Spatial Biology Up to 100

Collection: Scientific Event Highlights
Tags: Cancer, Immuno-Oncology

After two years of virtual conferences, thousands of scientists and physicians assembled in New Orleans in April for the 2022 American Association of Cancer Research (AACR) Annual Meeting. Spatial biology has established itself as a powerful tool for cancer research, enabling researchers to study…

10 Reasons We Are Excited About PhenoCycler-Fusion

Collection: Akoya Perspectives
Tags: Cancer, Immuno-Oncology

Spatial phenotyping is the power to visualize and quantify dozens of biomarkers in a single tissue sample while maintaining cellular and sub-cellular detail. Comprehensive spatial phenotyping can reveal cell diversity, co-expression patterns, cellular interactions, broader tissue architecture, and…

Five Publications That Left Their Mark on Spatial Biology

Collection: Akoya Perspectives, Publication Reviews
Tags: Cancer, Immuno-Oncology, Spatial Analysis

The number of publications in the field of spatial biology has been growing exponentially, demonstrating the rising interest in these approaches. As the year comes to a close, we’re reflecting on some of the most impactful findings in spatial biology from the last few years. Check out our top picks.

SITC 2021: Spatial Biology Poised to Address Challenges in Immuno-Oncology

Collection: Scientific Event Highlights
Tags: Cancer, Immuno-Oncology

Studies in recent years have established that the spatial arrangements of cells hold information crucial to understanding immunotherapy response. In a study published in the Journal for ImmunoTherapy of Cancer (JITC), Lu et al. found that multiplex imaging-based approaches like multiplex immunohistochemistry (mIHC) and immunofluorescence (mIF)…

3 Things You Should Know About Breast Tissue Organoids

Collection: Tips & Tricks
Tags: Cancer

Organoids are tissue-derived adult stem cells that can be grow into self-organizing organotypic structures. Due to their derivation from human tissue, organoids can more accurately model the interactions between healthy human tissue and cancer, enabling patient-specific drug testing and development of tailored therapeutic regimens. The…

Webinar Rewind: Pushing the Frontiers of CAR T-Cell Therapy

Collection: User Stories & Case Studies
Tags: Cancer, Immuno-Oncology

Pediatric cancer is an urgent and important problem that requires highly precise diagnostics and therapeutic approaches, however many of the necessary tools have yet to be developed. Around 60% of pediatric cancers are solid tumors, and the prognosis of these cancers is poor with mortality as high as 40%. Advanced solid tumors are highly complex and extremely…

Multi-Institutional Efforts to Standardize Multiplex Immunofluorescence for Spatial Biomarker Analysis

Collection: Akoya Perspectives, Publication Reviews
Tags: Cancer, Immuno-Oncology

In the era of immunotherapy, it’s essential to match the right patient to the right treatment. Effective biomarkers are needed to enable patient stratification and ensure that more patients benefit from precision medicine. While many novel techniques have been developed to aid scientists in their hunt for better immunotherapy biomarkers, spatial…

Multispectral Multiplex Immunofluorescence: Laying the Groundwork for Clinical Testing in Immuno-Oncology

Collection: Akoya Perspectives
Tags: Cancer, Immuno-Oncology

There is a pressing need for tests that can accurately predict response to immunotherapies, writes Cliff Hoyt, our VP of Translational & Scientific Affairs, in a review article for Frontiers in Molecular Biosciences. Established methods are limited in the amount of information they can pull out of formalin- fixed, paraffin-embedded (FFPE) tissue sections. Conventional…

From Stars to Cells: Johns Hopkins Researchers Discover Predictive Spatial Phenotypic Signatures with AstroPath

Collection: Publication Reviews, User Stories & Case Studies
Tags: Cancer, Immuno-Oncology

One of the biggest questions in immuno-oncology is figuring out how patients will respond to immunotherapy. Approaches like single-plex immunohistochemical stains don’t capture enough information to accurately predict response. To help solve this challenge, researchers at Johns Hopkins University (JHU) developed AstroPath, a novel platform which combines…

CODEX is now PhenoCycler
Phenoptics is now Phenolmager

Tag: Cancer