Authors: Rozenblatt-Rosen, Orit; Shin, Jay W.; Rood, Jennifer E.; Hupalowska, Anna; Regev, Aviv; Heyn, Holger
Issue: Nat Biotechnol. 2021 Feb;39(2):149-153.
Building the Human Cell Atlas (HCA) requires consistent and agile experimental designs, standardized operating protocols (SOPs), benchmarks and quality control metrics that can adapt to a rapidly evolving technological landscape. Here, the HCA Standards and Technology Working Group outlines pertinent technical challenges and their approach to defining benchmarks and quality control measures to ensure high-quality data for building a comprehensive and accurate human cell atlas and help guide other atlas projects in health and disease.