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Building a high-quality Human Cell Atlas

Authors: Rozenblatt-Rosen, Orit; Shin, Jay W.; Rood, Jennifer E.; Hupalowska, Anna; Regev, Aviv; Heyn, Holger

Online: https://www.nature.com/articles/s41587-020-00812-4

Issue: Nat Biotechnol. 2021 Feb;39(2):149-153.


Building the Human Cell Atlas (HCA) requires consistent and agile experimental designs, standardized operating protocols (SOPs), benchmarks and quality control metrics that can adapt to a rapidly evolving technological landscape. Here, the HCA Standards and Technology Working Group outlines pertinent technical challenges and their approach to defining benchmarks and quality control measures to ensure high-quality data for building a comprehensive and accurate human cell atlas and help guide other atlas projects in health and disease.