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Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrPC, in type 1 diabetes

Authors: Hiller, Helmut; Yang, Changjun; Beachy, Dawn E.; Kusmartseva, Irina; Candelario-Jalil, Eduardo; Posgai, Amanda L.; Nick, Harry S.; Schatz, Desmond; Atkinson, Mark A.; Wasserfall, Clive H.

Online: https://doi.org/10.1007/s00125-021-05501-8

Issue: Diabetologia. 2021 Oct;64(10):2279-2291.


Normal cellular prion protein (PrPC) is a conserved mammalian glycoprotein found on the outer plasma membrane leaflet through a glycophosphatidylinositol anchor. Although PrPC is expressed by a wide range of tissues throughout the body, the complete repertoire of its functions has not been fully determined. The misfolded pathogenic isoform PrPSc (the scrapie form of PrP) is a causative agent of neurodegenerative prion diseases. The aim of this study is to evaluate PrPC localisation, expression and trafficking in pancreases from organ donors with and without type 1 diabetes and to infer PrPC function through studies on interacting protein partners.