Mantra Quantitative Pathology Workstation
Part Number: CLS140089
Mantra™ quantitative pathology workstation with inForm® image analysis software enables easy visualization, quantification and phenotyping of multiple types of immune cells simultaneously in intact FFPE tissue sections for cancer immunology research.
Every Cancer Tells a Story If You Have the Tools To Read It
Mantra is a compact workstation which enables you to phenotype immune cells in situ in solid tumors using multiplexed biomarkers.
Traditional methods like flow cytometry and next-generation sequencing allow you to phenotype and quantify immune cells in homogenized samples, but you lose critical spatial information and context. Meanwhile, standard pathological analyses can deliver morphology data but do not allow the analysis of complex phenotypes.
With multispectral imaging, you can phenotype and quantify immune cells from images of FFPE tissue sections, maintaining tissue architecture, cellular spatial relationships and morphological context. This capability available on the Mantra provides spatial information, allowing for a better understanding of the role and types of immune cells within both the tumor and the tumor microenvironment so that new cancer immunotherapy treatments may be identified and researched.
The Mantra workstation is ideal for labs getting started with multispectral imaging and for assay development, allowing higher throughput systems such as Vectra® Polaris™ to be freed up. It incorporates multispectral imaging technology, image acquisition and analysis with the inForm® software, and can be used with a variety of stains including PerkinElmer's Opal™ reagent kits.
Stain, Image, Analyze, and Phenotype Immune Cells In-Situ with Phenoptics
The Mantra workstation is a part of PerkinElmer’s integrated Phenoptics™ workflow solution for immuno-oncology which includes staining reagents, imaging systems, and image analysis software.
Together, the in situ multiplexed biomarker staining, imaging systems such as Mantra, and image analysis software enable cell phenotypes to be simultaneously studied in solid tumors and their microenvironment. That allows for the quantification of cancer-immune interactions, revealing which disease mechanism is at play—to help discover and validate biomarkers and providing better data to support research into potential subpopulation stratification methodologies.
- Visualizes, analyzes, quantifies and phenotypes immune cells in situ in solid tissues
- Ideal for getting started with multispectral imaging or for assay development to free up a higher throughput system such as the Vectra Polaris
- Intuitive workflow optimized for the research pathologist
- Compact system that fits on your benchtop
- Eye-piece for easy visual checking of work as you go
- Automated Brightfield and multichannel fluorescence (up to 7 colors) capabilities
- Liquid crystal tuneable filter (LCTF) technology
- Phenochart™ whole slide viewer for slide navigation provides context for identification of regions of interest within a digital pathology workflow
- Automatic identification of specific tissue types using integrated inForm analysis software
- Supports PerkinElmer’s Phenoptics™ workflow solution for cancer immunology research
|21 CFR Part 11 Compatible||No|
|Detection Method||Fluorescence, Brightfield|
|Light Source||Metal Halide Lamp (Fl), Led (Bf)|
|Optical Imaging Classification||Brightfield, Fluorescence|
|Product Brand Name||Mantra|
|Research Areas||Cancer Research|
Resources, Events & More
Product Information Bulletin
The Mantra™ quantitative pathology workstation, with,inForm® image analysis software, enables easy,visualization, quantification and phenotyping of,multiple types of immune cells simultaneously in intact,FFPE tissue sections for cancer immunology research.,Mantra is a compact workstation where a researcher can phenotype immune cells in situ,in solid tumors using multiplexed biomarkers. Unlike existing flow cytometry and next,generation sequencing methods, which can phenotype and quantify immune cells in,homogenized samples, Mantra similarly does this using images of FFPE tissue sections,while maintaining tissue architecture and morphology. This provides spatial information,which could lead to a better understanding of the role and types of immune cells within,both the tumor and the tumor microenvironment so that new cancer immunotherapy,treatments may be identified and researched.,The Mantra is an integrated workstation incorporating multispectral imaging technology,novel image acquisition and inForm analysis software. It can be used with a variety of,stains including PerkinElmer's Opal™ reagent kits. The Mantra system is a part of,PerkinElmer’s cancer immunology portfolio which includes staining reagents, imaging,systems, and image analysis software.
- Publication: Linch, Stefanie N., et al. "Combination OX40 agonism/CTLA-4 blockade with HER2 vaccination reverses T-cell anergy and promotes survival in tumor-bearing mice." Proceedings of the National Academy of Sciences 113.3 (2016): E319-E327
- Publication: Miecnik, Bernhard, et al. "The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis." Science translational medicine 8.327 (2016)
- Publication: Esbona, Karla, et al. "COX-2 modulates mammary tumor progression in response to collagen density." Breast Cancer Research 18.1 (2016)
- Publication: Feng, Zipei, et al. "Multispectral Imaging of T and B Cells in Murine Spleen and Tumor." The Journal of Immunology 196.9 (2016): 3943-3950
- Publication: NEJM: Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
- Publication: Novartis Genoptix Shows Multiplexed IHC Test Better Predicts Immunotherapy Response
- Publication: Woods, Katherine, et al. "Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma." Journal for immunotherapy of cancer 4.1 (2016)
- Publication: Huang, Fangjin, et al. "Quantitative imaging for development of companion diagnostics to drugs targeting HGF/MET." The Journal of Pathology: Clinical Research (2016)
- Publication: NEJM: PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma
- Publication: Ören, Bilge, et al. "Tumour stroma-derived lipocalin-2 promotes breast cancer metastasis." The Journal of Pathology (2016)
- Poster: Optimization Strategy For Fluorescence Multiplex Immunohistochemistry Tissue Staining
- Poster: Automate Your Complete Cancer Research Workflow with Phenoptics™