The PhenoCycler Assay

Spatial Discoveries Simplified

Introducing PhenoCode Discovery Panels

Simplify your spatial biology journey through the ever-expanding biomarker landscape with PhenoCode Discovery Panels.

PhenoCycler - Reagents & Antibodie

The PhenoCyler® solution is a complete suite of antibodies and reagents optimized and validated for use with the PhenoCycler system. We also offer an ever-expanding menu of antibodies that includes essential immune markers. Users have the flexibility to create panels from ready-to-use PhenoCycler inventoried antibodies that have been validated for use across multiple tissue types including, but not limited to, mouse fresh-frozen, human fresh-frozen, and human formalin-fixed paraffin-embedded (FFPE). Custom conjugation kits are also available for labeling antibodies with PhenoCycler barcodes. PhenoCylcer barcodes allow for easy conjugation of antibodies, while the PhenoCycler Reporters are Fluorophore-conjugated oligonucleotides that visualize the antibodies.

Kits & Reagents

The PhenoCycler System utilizes reagents and buffers that have been optimized to be used in combination with PhenoCycler antibodies, barcodes and reporters. For each imaging cycle, three spectrally distinct PhenoCycler Reporters, are applied to the stained tissue to visualize the corresponding PhenoCycler antibody. A series of washes remove the PhenoCycler Reporters, followed by the application of the next set of reporter.

Catalog #
Product
Size
Storage Buffer for PhenoCycler
120 milliliters
Flow Cell 2pk for PhenoCycler-Fusion
2 flow cells
Flow Cell 10pk for PhenoCycler-Fusion
10 Flow Cells
10X Buffer for PhenoCycler
10 reactions
Assay Reagent for PhenoCycler
10 reactions
Nuclear Stain for PhenoCycler
10 reactions
Coverslips for PhenoCycler
138 coverslips 
96 well plates for PhenoCycler
10 plates 
96 well plate seals for PhenoCycler
10 plate seals 
Staining Kit for PhenoCycler
10 reactions
Antibody Conjugation Kit
10 reactions
Gaskets for PhenoCycler
10 gaskets
Coverslip Storage Box for PhenoCycler
1 storage box  
Sample Kit for PhenoCycler-Fusion
10 reactions
10X Buffer Kit for PhenoCycler-Fusion
10 reactions

PhenoCycler Antibodies

PhenoCycler antibodies are provided individually and can be tailored to design panels for the simultaneous analysis of 100+ biomarkers. Akoya provides fully validated PhenoCycler antibodies and a list of supplemental antibodies that have undergone varying levels of testing.

Community Antibodies
  • PhenoCycler user referenced 3rd party antibodies
  • End-user custom conjugation required
  • Minimal level of support by Akoya
Inventoried Antibodies
  • Manufactured and purified by an Akoya partner
  • End-user custom conjugation required
  • Limited support by Akoya
Screened Antibodies
  • Designed, conjugated and manufactured by Akoya
  • Fully validated for use on PhenoCycler system
  • Supported by Akoya

PhenoCycler antibodies have been tested in multiple types of human FFPE tissue and are conjugated to a distinct PhenoCycler Barcode (BX000). Twenty-five (25) test scan be performed with each kit.

Catalog #
Product
Size
Anti-Hu ATM(AKYP0122)-BX083—Atto 550 for PhenoCycler
25 tests
Anti-Hu b-Catenin1(AKYP0068)-BX020—Atto 550 for PhenoCycler
25 tests
Anti-Hu b-Catenin1(AKYP0068)-BX096—Atto 550 for PhenoCycler
25 tests
Anti-Hu Bcl-2(AKYP0120)-BX085—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu Bcl-2(AKYP0120)-BX085—Atto 550 for PhenoCycler
25 tests
Anti-Hu Beta-actin(AKYP0072)-BX010—Alexa Fluor™ 488 for PhenoCycler
25 tests
Anti-Hu Beta-actin(AKYP0072)-BX010—Alexa Fluor™ 750 for PhenoCycler
25 tests
Anti-Hu Beta-actin(AKYP0072)-BX117—Alexa Fluor™ 488 for PhenoCycler
25 tests
'Anti-Hu Beta-actin(AKYP0072)-BX117—Alexa Fluor™ 750 for PhenoCycler
25 tests
Anti-Hu Caveolin(AKYP0115)-BX086—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu Caveolin(AKYP0115)-BX086—Alexa Fluor™ 750 for PhenoCycler
25 tests
Anti-Hu CD3e(AKYP0062)-BX045—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu CD3e(AKYP0062)-BX080—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu CD4(AKYP0048)-BX003—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu CD8(AKYP0028)-BX026—Atto 550 for PhenoCycler
25 tests
Anti-Hu CD11c(AKYP0051)-BX024—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu CD14(AKYP0079)-BX037—Atto 550 for PhenoCycler
25 tests
Anti-Hu CD20(AKYP0049)-BX007—Alexa Fluor™ 488 for PhenoCycler
25 tests
Anti-Hu CD20(AKYP0049)-BX007—Alexa Fluor™ 750 for PhenoCycler
25 tests
Anti-Hu CD20(AKYP0049)-BX064—Alexa Fluor™ 750 for PhenoCycler
25 tests
Anti-Hu CD21(AKYP0061)-BX032—Atto 550 for PhenoCycler
25 tests
Anti-Hu CD31(AKYP0047)-BX001—Alexa Fluor™ 488 for PhenoCycler
25 tests
Anti-Hu CD31(AKYP0047)-BX001—Alexa Fluor™ 750 for PhenoCycler
25 tests
Anti-Hu CD34(AKYP0088)-BX025—Atto 550 for PhenoCycler
25 tests
Anti-Hu CD38(AKYP0110)-BX089—Atto 550 for PhenoCycler
25 tests
Anti-Hu CD39(AKYP0107)-BX099—Atto 550 for PhenoCycler
25 tests
Anti-Hu CD40(AKYP0095)-BX010—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu CD44(AKYP0073)-BX005—Atto 550 for PhenoCycler
25 tests
Anti-Hu CD45(AKYP0074)-BX021—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu CD45(AKYP0074)-BX021—Atto 550 for PhenoCycler
25 tests
Anti-Hu CD45RO(AKYP0059)-BX017—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu CD45RO(AKYP0059)-BX017—Atto 550 for PhenoCycler
25 tests
Anti-Hu CD56(AKYP0118)-BX028—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu CD56(AKYP0118)-BX028—Atto 550 for PhenoCycler
25 tests
Anti-Hu CD66(AKYP0080)-BX016—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu CD68(AKYP0050)-BX015—Alexa Fluor™ 647 for PhenoCycle
25 tests
Anti-Hu CD79a(AKYP0109)-BX090—Alexa Fluor™ 750 for PhenoCycler
25 tests
Anti-Hu CD107a(AKYP0004)-BX006—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu CD141(AKYP0124)-BX087—Atto 550 for PhenoCycler
25 tests
Anti-Hu CD163(AKYP0114)-BX069—Atto 550 for PhenoCycler
25 tests
Anti-Hu Collagen IV(AKYP0083)-BX042—Alexa Fluor™ 647
25 tests
Anti-Hu E-cadherin(AKYP0057)-BX014—Atto 550 for PhenoCycler
25 tests
Anti-Hu EpCAM(AKYP0119)-BX091—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu EpCAM(AKYP0119)-BX091—Alexa Fluor™ 750 for PhenoCycler
25 tests
Anti-Hu ER(AKYP0105)-BX084—Atto 550 for PhenoCycler
25 tests
Anti-Hu FOXP3(AKYP0102)-BX031—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu GATA3(AKYP0116)-BX049—Atto 550 for PhenoCycler
25 tests
Anti-Hu GP100(AKYP0123)-BX094—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu GP100(AKYP0123)-BX094—Atto 550 for PhenoCycler
25 tests
Anti-Hu Granzyme B(AKYP0086)-BX041—Atto 550 for PhenoCycler
25 tests
Anti-Hu HIF1A(AKYP0100)-BX062—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu Histone H3 Phospho (Ser28)(AKYP0060)-BX030—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu HLA-A(AKYP0078)-BX004—Alexa Fluor™ 750 for PhenoCycler
25 tests
Anti-Hu HLA-A(AKYP0078)-BX029—Atto 550 for PhenoCycler
25 tests
Anti-Hu HLA-DR(AKYP0063)-BX033—Alexa Fluor™ 647 for PhenoCycler
25 tests
'Anti-Hu HLA-DR(AKYP0063)-BX033—Alexa Fluor™ 750 for PhenoCycler
25 tests
Anti-Hu HLA-E(AKYP0096)-BX034—Atto 550 for PhenoCycler
25 tests
Anti-Hu ICOS(AKYP0090)-BX054—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu IDO1(AKYP0084)-BX027—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu IFNG(AKYP0093)-BX020—Atto 550 for PhenoCycler
25 tests
Anti-Hu iNOS(AKYP0104)-BX023—Atto 550 for PhenoCycler
25 tests
Anti-Hu Keratin 5(AKYP0121)-BX101—Atto 550 for PhenoCycler
25 tests
Anti-Hu Keratin 5(AKYP0121)-BX101—Alexa Fluor™ 750 for PhenoCycler
25 tests
Anti-Hu Keratin 8/18(AKYP0112)-BX081—Alexa Fluor™ 750 for PhenoCycler
25 tests
Anti-Hu Keratin 8/18(AKYP0112)-BX081—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu Keratin 14(AKYP0064)-BX002—Atto 550 for PhenoCycler
25 tests
Anti-Hu/Mu Ki67(AKYP0052)-BX047—Alexa Fluor™ 750 for PhenoCycler
25 tests
Anti-Hu/Mu Ki67(AKYP0052)-BX047—Atto 550 for PhenoCycler
25 tests
Anti-Hu LAG3(AKYP0089)-BX055—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu LIF(AKYP0065)-BX006—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu LIF(AKYP0065)-BX104—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu Mac2/Galectin-3(AKYP0067)-BX035—Atto 550 for PhenoCycler
25 tests
Anti-Hu MPO(AKYP0113)-BX098—Atto 550 for PhenoCycler
25 tests
Anti-Hu Pan-Cytokeratin(AKYP0053)-BX019—Alexa Fluor™ 488 for PhenoCycler
25 tests
Anti-Hu Pan-Cytokeratin(AKYP0053)-BX019—Alexa Fluor™ 750 for PhenoCycler
25 tests
'Anti-Hu Pan-Cytokeratin(AKYP0053)-BX066—Alexa Fluor™ 750 for PhenoCycler
25 tests
Anti-Hu PCNA(AKYP0085)-BX036—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu PD-1(AKYP0070)-BX046—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu PD-L1(AKYP0103)-BX043—Alexa Fluor™ 647 for PhenoCycler
25 tests
Anti-Hu Podoplanin(AKYP0007)-BX023—Atto 550 for PhenoCycler