Profiling Spatial Signatures in the Microenvironment of Non Small Cell Lung Carcinomas in Immunotherapy Responsive and Resistant Disease Cohorts

In this study, authors analyzed tissue using an 46-plex antibody panel with the PhenoCycler-Fusion system and derived targeted 6-plex panels to run on the PhenoImager HT platform aimed at T cell profiling, immune exhaustion, and immuno modulatory targets. Both analyses revealed similar spatial signatures across cohorts.