European User Group Meeting 2020: Immuno-Oncology

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Connecting users, advancing spatial knowledge

Join Us for This Virtual Event!

Join us to hear how researchers are using spatial biology to uncover new biological  insights as well as the latest innovations from Akoya and how they will impact your work.

Immuno-oncology Research Focus

November 5, 2020  6:30 – 8:30 AM PDT | 9:30 AM – 11:30 AM EDT |3:30 PM – 5:30 PM CEST
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Akoya:  What’s hot off the press and where is Akoya heading now?

Cliff Hoyt | Vice President Translational & Scientific Affairs
Akoya Biosciences

Applications of multiplexed IF in NSCLC
Sebastian Marwitz, PhD | Principal Investigator
Research Center Borstel; Germany

Sebastian Marwitz is a scientist at the Research Center Borstel – Leibniz Lung Centre currently working in the department of pathology.  He conducted his Bachelor of Science at the University of Hamburg and his Master of Science at the Christian-Albrechts-University Kiel. During his Msc thesis, he became interested in signaling pathways and cell biology and started his PhD project at the University of Lübeck, focusing on Transforming Growth Factor Beta signaling in lung diseases. He had the opportunity to continue his work in the department of pathology at the Research Center Borstel with projects embedded into the German Center for Lung Research (DZL). A main focus has been TGFB signaling in non-small cell lung cancer which led to a DFG-funded fellowship that enabled Sebastian to translocate to the lab of Bernard A Fox at the Earle A Chiles Research Institute in Portland, Oregon. Here, he was trained in multiplexed IHC and investigated the effect of SMAD3 phosphorylation in immune cells of NSCLC. After finishing the studies in Portland, he returned to Germany to resume his work on projects in the DZL as a principal investigator in the Airway Research Center North.

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New panel development on Ventana with Opal ™ & Polaris™
Stephanie Tissot, PhD | Head of Immune Landscape Laboratory
CHUV Lausanne; Switzerland

Stéphanie Tissot-Renaud received her PhD in life sciences in 2005 from the Institute of Pathology (University of Lausanne), where she studied the epigenetic transcriptional regulation of the catalytic subunit of the telomerase. In 2008, she completed her postdoctoral fellowship at the National Institute of Allergy and Infectious Diseases of the National Institute of Health in the United States of America. Coming back to Switzerland, she joined the institute of Biotechnologies of the University of Lausanne, to study the use of microRNA to detect and monitor breast cancer. In fall 2017, she integrated the laboratory of Immune Landscape of the Experiment Therapeutic center of the University Hospital of Lausanne. She is now co-leading the platform dedicated to the exploration of tumor microenvironment and identification of new biomarkers for the response to innovative therapies in different tumor indications. To achieve this goal, the laboratory is using multiplex Immuno-Fluorescence techniques with last generation scanner Polaris (Akoya) as well as Digital spatial profiling using the GeoMx DSP (Nanostring) for deeper protein and RNA analyses.

Exploring the immune landscape for translational research with Opal™ multiplexing on the Vectra® Polaris™
Matt Humphries, PhD | Scientific Lead for Tissue Hybridization & Digital Pathology
Queen’s University Belfast; UK

Matt Humpries (Univ. of Belfast): Matt is the Scientific Lead for Tissue Hybridisation & Digital Pathology in the Precision Medicine Centre of Excellence at Queen’s University Belfast. He is responsible for the TH & DP team, whose overarching goal is to deliver projects from clinical trials, programmatic research and industry. Prior to this role, Matt was a Post-Doctoral Research Fellow in the Molecular Pathology Group in the Patrick G Johnston Centre for Cancer Research at Queens, and a previous Post-Doctoral Research Fellow at the University of Leeds in the Breast Cancer Research Group in the Leeds Institute of Cancer and Pathology. Matt’s research interests are focused on the digital pathological assessment of immune biomarkers in solid tumours and the application of AI to pathology in both research and a clinical diagnostic settings. He obtained BSc, MSc and PhD degrees at Leeds, Bradford and Manchester, respectively.

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Astronomy Meets Pathology: An Interdisciplinary Effort to Discover Predictive Biomarker Signatures