User Stories & Case Studies

Webinar Rewind: Pushing the Frontiers of CAR T-Cell Therapy

Pediatric cancer is an urgent and important problem that requires highly precise diagnostics and therapeutic approaches, however many of the necessary tools have yet to be developed. Around 60% of pediatric cancers are solid tumors, and the prognosis of these cancers is poor with mortality as high as 40%. Advanced solid tumors are highly complex and extremely successful at evading the immune response. Dr. David Steffin, a pediatric oncologist and assistant professor…

Spatial Multiomics: The Need for Multidimensional Analysis with Single-Cell, Spatial Context

Researchers studying the dynamics of disease and development are increasingly relying on approaches that enable spatial analysis of RNA and protein markers within tissue. Tools like spatial proteomics and spatial transcriptomics are instrumental in answering complex biological questions. However, biological processes are driven by changes that occur simultaneously across multiple modalities. Transcriptomics and proteomics provide unique information…

Meet the Winners of the Akoya Image Contest

We recently held a social media image contest inviting our followers to show off a fun activity or theme using tissue images. After receiving some incredibly creative submissions, it’s time to announce the winners! Here are the top three participants with the most likes and/or reactions on their social media posts. 1st Place: Conrad Lee, …

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The Intricate Network of Immune Cells Revealed by Multiplex Tissue Microscopy

A ZEISS Microscopy User Story When our immune systems identify invaders – such as parasites, bacteria or viruses – it can spark inflammation, which brings fluid and immune cells to the area of infection. While this can be very effective in battling infection, it also has collateral damage on nearby healthy tissues. In our daily …

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From astronomy to pathology with AstroPath

From Stars to Cells: Johns Hopkins Researchers Discover Predictive Spatial Phenotypic Signatures with AstroPath

One of the biggest questions in immuno-oncology is figuring out how patients will respond to immunotherapy. Approaches like single-plex immunohistochemical stains don’t capture enough information to accurately predict response. To help solve this challenge, researchers at Johns Hopkins University (JHU) developed AstroPath, a novel platform which combines the Phenoptics multiplex immunofluorescence (mIF) workflow with sky-mapping …

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Customer Spotlight: HistoOne Pathology Services Advances Translational and Clinical Studies

HistoOne AB is an emerging pathology service provider based in Uppsala, Sweden with broad experience in in situ analysis techniques. At Akoya, we were excited to hear that their first scientific publication described an objective quantification of the tumor stroma fraction across 16 solid cancers types from 2732 patients, using the Vectra® Polaris™ Imaging system. …

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Astronomy & Pathology Join Forces to Predict Immunotherapy Response: Q&A with Spatial Biology Experts

Researchers at Johns Hopkins University (JHU) recently published findings from AstroPath, the result of a unique collaboration between the astrophysics and pathology departments at JHU. The platform enables deep whole-slide imaging and spatial profiling of microscopic tumor sections by combining the Phenoptics™ platform for multiplex immunofluorescence with sky-mapping algorithms derived from the Sloan Digital Sky …

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Webinar Rewind: The Human Cell Atlas

The mission of the Human Cell Atlas is to create comprehensive reference maps of all human cells to describe and define the cellular basis of health and disease. Dr. Kai Kessenbrock, Assistant Professor of Biological Chemistry at UC Irvine, is a Co-Principal Investigator on the Human Breast Cell Atlas Project, which seeks to map all …

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"Cell Defence" painting by James Cochran

Customer Spotlight: “Cell Defence” – When Multispectral Imaging Inspired Art at the Institute of Cancer Research

Credit: ‘Cell Defence’ by James Cochran, Artist To support fund-raising initiatives for its new Centre for Cancer Drug Discovery, the Institute of Cancer Research worked with street artist James Cochran to create an extraordinary piece of art using a laboratory pipette. Titled "Cell Defence", the artwork was inspired by an image from the Cancer Biomarkers …

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