Publication Reviews

7-color multiplex immunofluorescence images of colorectal cancer from Crohn's like reaction and diffuse inflammatory infiltration patient groups and accompanying voronoi plots.

Spatial Analysis of Cellular Neighborhoods: Uncovering Complex Interactions in Tissue Biology

The tumor microenvironment is undeniably complex. Specialized immune cells interact directly and indirectly with tumor cells in a constantly evolving relationship that influences the biology of the tumor. Spatial context is essential to uncovering the mysteries of cell behavior and interactions. Just as individuals may behave differently in cities, suburbs, and rural areas, individual cells adopt different roles depending on their surroundings, or neighborhoods. A pioneering study published in Cell by Dr. Garry Nolan’s lab at Stanford University introduced a novel analysis framework…

Multi-Institutional Efforts to Standardize Multiplex Immunofluorescence for Spatial Biomarker Analysis

In the era of immunotherapy, it's essential to match the right patient to the right treatment. Effective biomarkers are needed to enable patient stratification and ensure that more patients benefit from precision medicine. While many novel techniques have been developed to aid scientists in their hunt for better immunotherapy biomarkers, spatial phenotyping has emerged as …

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From astronomy to pathology with AstroPath

From Stars to Cells: Johns Hopkins Researchers Discover Predictive Spatial Phenotypic Signatures with AstroPath

One of the biggest questions in immuno-oncology is figuring out how patients will respond to immunotherapy. Approaches like single-plex immunohistochemical stains don’t capture enough information to accurately predict response. To help solve this challenge, researchers at Johns Hopkins University (JHU) developed AstroPath, a novel platform which combines the Phenoptics multiplex immunofluorescence (mIF) workflow with sky-mapping …

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Webinar Rewind: The Human Cell Atlas

The mission of the Human Cell Atlas is to create comprehensive reference maps of all human cells to describe and define the cellular basis of health and disease. Dr. Kai Kessenbrock, Assistant Professor of Biological Chemistry at UC Irvine, is a Co-Principal Investigator on the Human Breast Cell Atlas Project, which seeks to map all …

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Image of a normal brain and a brain with advanced chronic traumatic encephalopathy.

Tau Isoforms in Chronic Traumatic Encephalopathy: Paving the Way for Diagnostics, Targeted Therapy

The link between contact sports and chronic traumatic encephalopathy has gained increased scrutiny in recent years, largely due to research into the subject by Dr. Ann McKee of Boston University. In this post, we discuss a recent publication from Dr. McKee's team which used multiplex immunohistochemistry in combination with other approaches to gain a better …

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