Akoya Perspectives

Spatial Multiomics: The Need for Multidimensional Analysis with Single-Cell, Spatial Context

Researchers studying the dynamics of disease and development are increasingly relying on approaches that enable spatial analysis of RNA and protein markers within tissue. Tools like spatial proteomics and spatial transcriptomics are instrumental in answering complex biological questions. However, biological processes are driven by changes that occur simultaneously across multiple modalities. Transcriptomics and proteomics provide unique information…

Multi-Institutional Efforts to Standardize Multiplex Immunofluorescence for Spatial Biomarker Analysis

In the era of immunotherapy, it's essential to match the right patient to the right treatment. Effective biomarkers are needed to enable patient stratification and ensure that more patients benefit from precision medicine. While many novel techniques have been developed to aid scientists in their hunt for better immunotherapy biomarkers, spatial phenotyping has emerged as …

Multi-Institutional Efforts to Standardize Multiplex Immunofluorescence for Spatial Biomarker Analysis Read More »

Multispectral Multiplex Immunofluorescence: Laying the Groundwork for Clinical Testing in Immuno-Oncology

There is a pressing need for tests that can accurately predict response to immunotherapies, writes Cliff Hoyt, our VP of Translational & Scientific Affairs, in a review article for Frontiers in Molecular Biosciences. Established methods are limited in the amount of information they can pull out of formalin- fixed, paraffin-embedded (FFPE) tissue sections. Conventional immunohistochemistry …

Multispectral Multiplex Immunofluorescence: Laying the Groundwork for Clinical Testing in Immuno-Oncology Read More »

Customer Spotlight: HistoOne Pathology Services Advances Translational and Clinical Studies

HistoOne AB is an emerging pathology service provider based in Uppsala, Sweden with broad experience in in situ analysis techniques. At Akoya, we were excited to hear that their first scientific publication described an objective quantification of the tumor stroma fraction across 16 solid cancers types from 2732 patients, using the Vectra® Polaris™ Imaging system. …

Customer Spotlight: HistoOne Pathology Services Advances Translational and Clinical Studies Read More »

Astronomy & Pathology Join Forces to Predict Immunotherapy Response: Q&A with Spatial Biology Experts

Researchers at Johns Hopkins University (JHU) recently published findings from AstroPath, the result of a unique collaboration between the astrophysics and pathology departments at JHU. The platform enables deep whole-slide imaging and spatial profiling of microscopic tumor sections by combining the Phenoptics™ platform for multiplex immunofluorescence with sky-mapping algorithms derived from the Sloan Digital Sky …

Astronomy & Pathology Join Forces to Predict Immunotherapy Response: Q&A with Spatial Biology Experts Read More »